Remeron has been linked to suicidal behavior, violent behavior, liver damage, bone marrow damage, and birth defects, including congenital heart defects and Persistent Pulmonary Hypertension of the Newborn (PPHN).
Remeron SolTab (generic: Mirtazapine) is an oral depression medication produced by Organon Inc. It received approval from the Food and Drug Administration (FDA) on January 12, 2001 to treat mental depression. Major side effects include birth defects, suicide and violent behavior in adolescents, liver damage, and bone marrow damage.
Its off-label uses often include:
- Panic attacks, anxiety
- Bipolar depression
- Sleep disorders
- Chronic fatigue
- Irritable bowel syndrome
Serious Side Effects of Remeron
- Suicidal ideation
- Suicide attempts
- Liver damage
- Loss of coordination, fainting
- Blood and Bone Marrow problems
- Birth defects, including Persistent Pulmonary Hypertension of the Newborn (PPHN)
Remeron Birth Defects
SSRI antidepressants have been linked to congenital heart defects and lung defects. Some types of heart defects linked to Remeron include:
- Heart Murmur
- Tricuspid Valve Stenosis
- Atrial septal defect
- Ventricular septal defect
- Tetralogy of Fallot
- Hypoplastic Left Heart Syndrome
- Hypoplastic Right Heart Syndrome
- Transposition of the Great Arteries
- Coarctation of the aorta
Persistent Pulmonary Hypertension of the Newborn (PPHN) is another potential side effect of this medication. A study published in the New England Journal of Medicine found that PPHN was more common in babies born to women who took an antidepressant during their first trimester of pregnancy.
PPHN is a serious birth defect that occurs immediately after a baby is born, when the baby’s circulatory system fails to provide adequate oxygen to the blood. Before a baby is born, it receives oxygen from its mother. At birth, the baby’s circulatory system must undergo a dramatic change, in which it begins to use its lungs for the first time and supply its own oxygen. For a baby with PPHN, the pressure in the lungs stays too high, and not enough blood goes into the lungs. Because very little blood is going into the lungs, when the baby breathes, the oxygen only reaches a small amount of blood. This causes the baby to be oxygen-deprived. In severe cases, the lack of oxygen can be life-threatening.
If you took Remeron during pregnancy and had a child with PPHN or other birth defect, contact The Schmidt Firm, PLLC for a Remeron attorney who can help you get the compensation you deserve in a Remeron lawsuit.
Remeron and Suicide in Adolescents
Remeron and other SSRI antidepressants are widely suspected of contributing to suicidal behavior and violent behavior in adolescents. The use of antidepressants has not been approved for patients under 18 years of age, with the exception of Prozac (which has contributed to 1/3 of all drug-related suicides). This means that a healthcare professional who prescribes Remeron to adolescents is taking risks with the child’s safety by prescribing it for an unapproved use.
The FDA warns that patients with depression may experience a worsening of their symptoms, or the emergence of suicidal ideation and behavior, and that patients who are taking antidepressants be observed closely for suicidal or violent behavior, especially at the beginning of treatment. Patients should be watched for the emergency of agitation, irritability, and aggressive behavior.
If you or someone you know has been the victim of violent, destructive, or suicidal behavior while taking this medication, you may be entitled to compensation in a Remeron lawsuit. Contact a Remeron lawyer at The Schmidt Firm, PLLC for a free case consultation.
Remeron Bone Marrow Damage
Bone marrow damage has been reported during treatment of most antidepressants, including Remeron, usually occurring 4-6 weeks after treatment. The symptoms of bone marrow damage include fever, sore throat, stomach problems, and other signs of infection. If these symptoms occur, Remeron treatment should be discontinued. During clinical trials, the patients who developed bone marrow suppression recovered fully. Even so, experts warn that people who have had bone marrow problems should be cautious when considering whether to use Remeron.
Remeron Liver Damage
Remeron is known to increase the body’s production of liver enzymes. These enzymes, called “alanine transaminase” (ALT) are present in liver cells. When these cells are damages, they leak ALT into the bloodstream, where it can be detected in a blood test.
The use of Remeron has occasionally caused the levels of ALT to increase to more than three times the normal limit. Though the majority of these cases were treatable before they cased severe liver damage, it is recommended that people taking Remeron undergo periodic liver enzyme testing.