Trican Lawsuit

Trican (fluconazole) is often prescribed to pregnant women with yeast infections, meningitis, and other serious fungal infections. Unfortunately, there is a growing amount of evidence linking high-doses of Trican during the first trimester to an increased risk of a specific set of birth defects.

What You Can Do & How a Trican Lawsuit Can Help

The Schmidt Firm, PLLC is currently accepting Trican induced injury cases in all 50 states. If you or somebody you know had a baby with a birth defect after taking Trican during pregnancy, you should contact our lawyers immediately for a free case consultation. Please use the form below to contact our Defective Drug Litigation Group or call us toll-free 24 hours a day at (866) 920-0753.

What is Trican (fluconazole)?

Trican is the brand-name of fluconazole (also sold as Diflucan). This anti-fungal medication is manufactured by Pfizer and has been on the market since 1990. It is primarily used to treat Candida (yeast) infections of the vagina, throat, esophagus, abdomen, lungs, blood, and other organs.

Trican and Birth Defects

Trican birth defects resemble Antley-Bixler Syndrome, and include:

• Short, broad head (brachycephaly)
• Abnormal facial features
• Abnormal skull cap
• Cleft lip
• Cleft palate
• Bowed thigh bones
• Thin ribs
• Long bones
• Muscle weakness
• Joint stiffness or immobility (arthrogryposis)
• Congenital heart disease
• Heart defects
• Tetralogy of Fallot

Early Case Reports Linking Trican and Birth Defects

Case reports have linked Trican and birth defects since the 1990s, but Pfizer did not add warnings about this risk until recently. Early case reports of birth defects include:

• 1992 — Infant exposed to 400-mg/day fluconazole born with birth defects of the bones (bowed femur), skull, face, cleft lip, cleft palate, and more.
• 1996 — Two more infants exposed to high-dose fluconazole (800 mg/day) born with severe birth defects, including one with a cranial defect.
• 1997 — Infant exposed to 1200 mg/day fluconazole born with birth defects of the joints, face, skull, and more.
• 2005 — Infant exposed to 400-mg/day fluconazole born with skull defects and elongated bones.
• And more

Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk by Gerald G. Briggs, Roger K. Freeman, and Sumner J. Yaffe, published in March 2012.

FDA Safety Warnings for Trican

According to a Drug Safety Communication published by the U.S. Food and Drug Administration (FDA) in August 2010, taking over 400-mg/day of Trican during the first trimester might increase the risk of having a baby with a birth defect.

High-dose Trican is now Pregnancy Category D, which means that there is evidence linking it to an increased risk of birth defects. The Pregnancy Category for a single 150-mg dose to treat yeast infections remains C, which means that studies in humans have not found an increased risk of birth defects.

Single-Dose Trican Linked to Heart Defect (Tetralogy of Fallot)

The New England Journal of Medicine published a study in August 2013 linking single-dose of 150-mg fluconazole to a 3.16-fold increased risk of Tetralogy of Fallot, a severe heart defect. However, the researchers’ conclusions were based on only 7 cases, and more studies are needed to investigate the risk of heart defects.

Do I have a Trican Lawsuit?

The Schmidt Firm, PLLC is currently accepting Trican induced injury cases in all 50 states. If you or somebody you know had a baby with a birth defect after taking Trican during pregnancy, you should contact our lawyers immediately for a free case consultation. Please use the form below to contact our Defective Drug Litigation Group or call us toll-free 24 hours a day at (866) 920-0753.

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