Wellbutrin is an antidepressant medication that may increase the risk of having a baby with a birth defect if it is used during pregnancy.
The antidepressant Wellbutrin (buproprion) belongs to a class of stimulant drugs known as aminoketones, which work by increasing norepinephrine and dopamine in the brain. It is used to treat major depression.
Wellbutrin and Pregnancy
Wellbutrin is in Pregnancy Class C, meaning that the risk of birth defects in humans is unknown. Studies in animals found evidence of birth defects and skeletal malformations in low doses, approximately equal to the equivalent dose in humans.
Wellbutrin Linked to Heart Defects
One study published in the American Journal of Obstetrics & Gynecology found that infants exposed to Wellbutrin in early pregnancy were 2.6-times more likely to be born with a left outflow tract heart defect.