Millions of men with symptoms of “Low T” have received prescriptions for testosterone replacement therapy products like Axiron. If you were not aware of studies linking Axiron and stroke, you are not alone — many lawsuits allege that drug-makers have not done enough to provide warnings about this life-threatening side effect.
Axiron and Strokes
Blood clots are a well-known side effect of Axiron and other testosterone replacement therapy (TRT) products. Testosterone, a Schedule III controlled substance, increases the risk of blood clots by thickening the blood, elevating blood pressure, and increasing the number of red blood cells. Unfortunately, Axiron has become controversial after studies found that testosterone may also increase the risk of ischemic strokes (blood clots in the brain).
Axiron Linked to 30% Increased Risk of Stroke
November 2013 — Journal of the American Medical Association (JAMA) published a study linking testosterone replacement therapy to a 30% increased risk of stroke, heart attack, and death compared to men who were not on testosterone.
The conclusions of the study prompted an investigation and Safety Communication from the FDA in January 2014. According to the FDA, conclusions of the study were based on men who were an average of 60 years old. Many of them had pre-existing heart disease.
There are two main types of stroke: ischemic stroke (blood clots in the brain) and hemorrhagic stroke (bleeding in the brain). Both types cut off the circulation of oxygen-rich blood to the brain, which can cause permanent brain damage. Axiron is associated with ischemic strokes and also transient ischemic attacks (TIA). These “mini-strokes” occur when a blood clot temporarily blocks a blood vessel in the brain, usually for under 5 minutes, and then dissolves spontaneously.
Over two-thirds of people who have a stroke develop brain damage, long-term complications, or disabilities. These may include paralysis, memory loss, muscle weakness, speech problems, cognitive disability, and more. These complications vary depending on the area of brain damage and the time delay until treatment.
- Face drooping
- Arm weakness (arms drop when raised above the head)
- Speaking problems
- Sudden numbness or weakness of the face, arm, leg, or one side of the body
- Sudden confusion
- Problems walking, balancing, or coordinating movements
- Sudden severe headache