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Nexium Lawsuits

Nexium Lawsuits

The heartburn drug Nexium has been linked to a 20-50% increased risk of Chronic Kidney Disease (CKD). In 2014, the FDA updated the label on Nexium to include nephritis (kidney inflammation) and acute kidney injury. Unfortunately, both of these serious side effects can lead to kidney failure or even death.

What You Can Do & How We Can Help

The Schmidt Firm, PLLC is currently accepting Nexium induced injury cases in all 50 states. If you or somebody you know has been diagnosed with kidney failure, renal disease, or nephritis, you should contact our lawyers immediately for a free case consultation. Please use the form below to contact our Defective Drug Litigation Group or call toll free 24 hours a day at (866) 920-0753.

UPDATE: Study Links Nexium and Kidney Failure

April 2016 — The Journal of the American Society of Nephrology has published a study linking long-term use of PPI antacid medications like Nexium with a 96% increased risk of kidney failure and a 26% increased risk of chronic kidney disease. Click here to read more.

Overview

Nexium belongs to a group of drugs called proton pump inhibitors (PPIs). It decreases the amount of acid produced in the stomach and are used to treat conditions like gastroesophageal reflux disease (GERD) or acid reflux disease. Some of the most serious side effects include:

Studies Link Nexium and Kidney Disease

In January 2016, a study published in JAMA Internal Medicine found a 20-50% increased risk of Chronic Kidney Disease (CKD) associated with some of the most popular heartburn drugs on the market. People who took PPIs twice a day were 46% more likely to develop CKD, and once-daily users had a 15% higher risk. Conclusions were based on data from 10,500 patients who used PPIs between 1996 and 2011.

Long-term use of PPIs was associated with a tripled increased risk of nephritis in a study published in April 2015 by the medical journal CMAJ Open. Researchers also found a 2.5-fold increased risk of acute kidney injury. The study conclusions were based on data from 290,000 adults in Canada over 66 years old who started a PPI between 2002 and 2011.

FDA Adds Nephritis to Nexium Label

The first case reports linking Nexium and kidney inflammation (nephritis) were published in 1992. By 2004, AstraZeneca reported 15 cases worldwide. The number of case reports has continued to grow, including some reports involving patients who needed long-term dialysis for kidney failure. In December 2014, the FDA added warnings about acute interstitial nephritis to the label. The agency warned that nephritis can occur at any time when patients are taking Nexium. Without treatment, it can cause kidney failure.

Kidney Side Effects

FDA Warning: Bone Fracture Risk

In 2010, the FDA found that patients who had used Nexium in high doses for more than a year may be at risk of hip, wrist and spine fractures. Patients over the age of 50 are at the greatest risk of developing fractures.

Furthermore, the FDA recently announced PPIs may cause low serum magnesium levels (hypomagnesemia) if taken for prolonged periods of time (in most cases, longer than one year). Low serum magnesium levels can result in serious adverse side effects including muscle spasm (tetany), irregular heartbeat (arrhythmias), and convulsions (seizures).

FDA Updates Label to Include More Side Effects

In November 2014, the FDA added new warnings about side effects but did not issue a “Black Box” warning about bone fractures and pneumonia. Side effects added to the label include:

  • Clostridium difficile-associated diarrhea
  • Vitamin B12 deficiency
  • Acute interstitial nephritis
  • Recommended treatment length for gastroesophageal reflux disease (GERD)
  • Drug interactions with methotrexate (a cancer drug that can remain in the body and become toxic) and mycophenolate mofetil
  • Drug interactions with Plavix (clopidogrel), a blood-thinner that may be less effective in patients on heartburn drugs

Bone Fractures

In a 2006 study published by the Journal of the American Medical Association, 135,000 people at least 50 years or older were studied. Patients who took PPIs for longer than one year at a high dosage were found to be 2.65 times more likely to break a hip. Additionally, the risk of fracture increased with the length of time PPIs were taken.

Because of the study’s findings, the FDA has said that all PPIs will now carry a new warning label about the potential risk of bone fractures. In March 2011, The FDA determined over-the-counter (OTC) PPI medications do not need this warning. They concluded that fracture risk was not likely for short-term (14 days or less) and low doses.

Bone fractures occur because of a lack of calcium in the body, due to PPI usage. When the amount of stomach acid is reduced, the body undergoes a health decline because of a decrease in the amount of nutrients absorbed. For example, low stomach acid limits the body’s ability to absorb calcium, which can lead to a softening of the bones.

Study Links Nexium and Hip Fracture Risk for Older Women

In January 2012, the British Medical Journal has published the results of a study which found that many popular heartburn medications may increase the risk of hip fractures, especially in older women. Post-menopausal women who took one of these medications regularly for at least two years were 35% more likely to suffer a hip fracture. The risk was even higher for women who smoked.

Bone Fracture Lawsuits Centralized in Federal Court

In December 2012, nearly 40 Nexium bone fracture lawsuits and class-actions have been centralized in the U.S. District Court for the Central District of California before Judge Dale S. Fisher.

Low Magnesium Levels

In March 2011, the FDA issued a drug safety alert suggesting that Nexium and other PPIs may cause low serum magnesium levels (hypomagnesemia) if taken for a prolonged period of time — usually longer than one year, although there were cases of patients developing hypomagnesemia after only 3 months of usage.

Do I have a Nexium Lawsuit?

The Schmidt Firm, PLLC is currently accepting Nexium induced injury cases in all 50 states. If you or somebody you know has been diagnosed with kidney failure, renal disease, or nephritis, you should contact our lawyers immediately for a free case consultation. Please use the form below to contact our Defective Drug Litigation Group or call toll free 24 hours a day at (866) 920-0753.

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Free Case Evaluation

The Schmidt Firm, PLLC has been recognized as one of the nation’s leading plaintiff’s law firms and handles cases in all 50 states. We are very proud of our legal achievements, but equally self-respecting of our firms reputation for providing personal attention to each and every client we represent.

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