Call Today for a FREE Confidential Case Review
Toll-Free 24/7 (866) 920-0753

Rare Blood Disorder Linked to Aczone Acne Gel


January 30, 2015 — The New England Journal of Medicine has published a report linking Aczone, a popular acne gel, with a rare blood disorder known as methemoglobinemia.

Aczone is a topical gel that contains 5% dapsone, an antibiotic that has been on the market for decades. Dapsone is well-known to increase the risk of methemoglobinemia, but this report is the first-known case linked to Aczone.

The case report involves a 19 year-old woman who visited the emergency room with blue lips and fingers, mild headache, and shortness of breath. She had been using a “pea-sized” amount of Aczone for the last seven days, but failed to tell her doctors.

After going through a number of tests, doctors detected dapsone in her urine and diagnosed her with methemoglobinemia.

Methemoglobinemia is a rare but serious blood disorder that can be inherited or acquired as a side effect of certain medications. It causes abnormal levels of the protein methemoglobin, which carries oxygen but is unable to deliver it effectively to body tissues.

Methemoglobinemia symptoms may include:

  • Bluish coloring of the skin
  • Headache
  • Fatigue
  • Shortness of breath
  • Lack of energy


Free Case Evaluation

The Schmidt Firm, PLLC has been recognized as one of the nation’s leading plaintiffs' law firms and handles cases in all 50 states. We are very proud of our legal achievements, but equally self-respecting of our firm's reputation for providing personal attention to each and every client we represent.

No matter what type of case you have, you may contact us with confidence by filling out the email contact form below or calling us directly by dialing toll free 24 hrs/day (866) 920-0753.