Neuroleptic malignant syndrome (NMS) is a rare, life-threatening neurological disorder usually caused by neuroleptic or antipsychotic medications.
Signs & Symptoms of Neuroleptic Malignant Syndrome
The following is a list of signs and symptoms related to Neuroleptic Malignant Syndrome. Unfortunately, symptoms are sometimes misinterpreted by doctors as symptoms of mental illness, delaying treatment.
- Muscular rigidity
- Sweating
- High fever
- Instability of the autonomic nervous system
- Unstable blood pressure
- Changes in cognition
- Agitation
- Delirium
- Coma
Neuroleptic Malignant Syndrome Treatment Options
Immediate intensive care is usually required for those who have developed NMS. The first step is to discontinue the neuroleptic or antipsychotic drug and to treat the fever aggressively. A muscle relaxant may be prescribed. Dopaminergic drugs, such as a dopamine agonist, have been reported to be useful.

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